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Check Your Symptoms in 30 Seconds

Do you
have MS?

In 30 seconds find out if you might have MS by clicking on all of the symptoms that apply.

The patient might experience complete / partial recovery of symptoms followed by more episodes of new or worsening symptoms. Hence please also click those symptoms which you may have experienced in the past. The gap between episodes varies from a few days to even a few years.

Experiencing any of the above symptoms indicate that you may suffer from MS, however please consult your neurologist for a confirmed diagnosis.

Disclaimer: Diagnosis of MS is only done by a qualified Neurologist. The purpose of the above screening is only to help potential patients reach the appropriate doctors at their nearest location.

Disease progression
in Multiple Sclerosis

Multiple sclerosis (MS) is a complicated neurodegenerative disease (degeneration of nerve tissue). Although each person with MS experiences different symptoms and course of the disease, the underlying biology and the ways the disease can be measured are the same for everyone.

Disability Progression

Most people with MS experience an increase in physical disability at some point in time. When it happens, what kind of disability it is and how much it changes differs for everybody. The graphs below show how disability progression can vary between individuals.

Disability - Time
Disability worsening related to relapse (episodes of new of worsening neurological symptom), with or without complete recovery.
Disability - Time
Disability worsening related to relapse without complete recovery, followed by disability progression independent of relapses.
Disability - Time
Disability progression independent of relapse.

Disease Activity


In MS, the immune system attacks nerve cells in the brain, spinal cord and optic nerves. This disease activity can cause symptoms and disability.

There are two main types of disease activity

Visible
Such as a relapse
Underlying
Detected with MRI brain scans

Types of Disability


Physical disability gets worse (progression) when disease activity causes more and more nerve cells to die (neurodegeneration)

People may experience disability in different ways, depending on what part of the brain, spinal cord or optic nerves is affected.

Anatomy

Measuring Disability

Disability is measured in different ways.

Expanded Disability Status Scale (EDSS)

Expanded Disability Status Scale (EDSS)

Measures the degree of physical disability based on a neurological exam of seven functional systems throughout the body, plus a person’s walking ability. It is a clinical rating scale used to assess disability in MS.

Nine-Hole Peg Test (9-HPT)

Nine-Hole Peg Test (9-HPT)

Measures arm, wrist and hand function by timing the speed in which a person can move nine pegs into nine holes and then remove them, using one hand at a time.

Timed 25-Foot Walk (T25-FW)

Timed 25-Foot Walk (T25-FW)

Determines walking speed by measuring how fast a person with MS can walk 25 feet.

Disease-Modifying Treatment

Disease activity and disability progression can occur at the earliest stage of the disease. So the most important goal of MS treatment is to control disease activity as early as possible. Extensive clinical experience has shown that Disease Modifying Treatments can help people with MS control disease activity.

Disability progression without treatment
Disability progression without treatment

Scroll below to see an example of the impact of early treatment with a disease-modifying treatment (DMT) on disease progression.
Disability progression with DMT
Disability progression with DMT

Early treatment with an effective DMT may reduce disease activity and disability progression.

References

  1. Giovannoni, G, et al. Brain Health: Time Matters in Multiple Sclerosis. 2015; pp 14.
  2. MS International Federation. What is MS? Available at https://www.msif.org/about-ms/what-is-ms/
  3. Medline Plus. Multiple Sclerosis. Available at https://medlineplus.gov/ency/article/000737.htm
  4. National MS Society. Managing Relapses. Available at http://www.nationalmssociety.org/Treating-MS/Managing-Relapses. Accessed September 2016.
  5. De Stefano N., et al. Evidence of Axonal Damage in the Early Stages of Multiple Sclerosis and Its Relevance to Disability. Arch Neurol. 2001;58(1):65-70. Available at http://jamanetwork.com/journals/jamaneurology/fullarticle/778355
  6. National MS Society. MS Symptoms. Available at http://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms
  7. National MS Society. Functional Systems Score (FSS) and Expanded Disability Status Scale. Available at http://www.nationalmssociety.org/For-Professionals/ Researchers/Resources-for-Researchers/Clinical-Study-Measures/Functional-Systems-Scores-(FSS)-and-Expanded-Disab. Accessed September 2016.
  8. National MS Society. 9-Hole Peg Test (9-HPT). Available at http://www.nationalmssociety.org/For-Professionals/Researchers/Resources-forResearchers/Clinical-Study-Measures/9-Hole-Peg-Test-(9-HPT). Accessed September 2016.
  9. National MS Society. Timed 25-Foot Walk (T25-FW). Available at htp://www.nationalmssociety.org/For-Professionals/Researchers/Resources-for-Researchers/Clinical-Study-Measures/Timed-25-Foot-Walk-(T25-FW). Accessed September 2016.
  10. MS Brain Health. Time Matters in Multiple Sclerosis. Available at http://msbrainhealth.org/perch/resources/time-matters-in-ms-report-may16.pdf
  11. MS Coalition. The Use of Disease-Modifying Therapies in Multiple Sclerosis: Principles and Current Evidence. Available at http://www.nationalmssociety.org/getmedia/5ca284d3-fc7c-4ba5-b005-ab537d495c3c/DMT_Consensus_MS_Coal